Search for ^([^\s]*)(\s)
Replace with $1 AND_WHAT_EVER_STRING_YOU_WANT
Here is an example of searching for first space in a line and adding “',” to the string
HOWTO : Replace first space in a line using Notepad++
Search for ^([^\s]*)(\s)
Replace with $1 AND_WHAT_EVER_STRING_YOU_WANT
Here is an example of searching for first space in a line and adding “',” to the string
For the second space, you can use ((\s){2}) as the find string. and $1_PLUS_WHATEVER_YOU_WANT_TO_REPLACE as the replace with option.
Better regex for second space is (\S\s\S+). Non space + space + Non space